KIPeriOP is a research project funded by the German Federal Ministry of Health (BMG) with the aim of improving perioperative risk management and reducing perioperative mortality and permanent damage. Clinical guidelines already support perioperative decision-making and will be complemented in the project by the trustworthy use of artificial intelligence, including the prediction of postoperative risks based on preoperative risk factors. The project consortium combines outstanding clinical, technical, ethical and economic expertise and is led by the University Hospital of Würzburg (clinical coordination) and the Fraunhofer Institute for Digital Medicine MEVIS (technical coordination).